Fred.
I have a 180g and a 10 and 5 lb bottle that I use and switch when one empties.
10 lb lasts about 4-6 weeks (or less) for me to keep at 30 ppm c02...... I wait till both are dry and fill at the same time.... as it is inconvenient as Vaughn mentioned.
FYI - I bought the 10lb pre-filled USED from the fire extinguisher place that does my refills for about $55. Much less expensive than new, but uglier/older.
I would use a 20 lb, but does not fit under the tank
I am going to buy another 10 lb next refill, and use the 5 lb for a smaller project, and swap between the two 10 pounders....
Good luck. Hope this helps.