Mix up a water/liquid soap solution, put this into a spray bottle (HD or local hardware store), then spray all connections and look for bubbles/frothing at these joints. It sounds like it's at the tank connection with that volume of CO2 leaking. Oh, I like to use the special CO2 tubing to my reactor. I also use thin tie wraps at each neophrene connection to secure things. I would assume you're not pumping that much CO2 into the tank, or all fish would be belly up long ago. :gw
