I think the answer might depend on wich chemicals you are using.
I usually mix KNO3, KH2PO4, K2SO4, MGSO4, Seachem Flourish and Iron. I have put some though to figure if there would be any reaction, and excluding the Flourish"es", I couldn't figure any reaction. I also haven't found any information regarding reaction between these chemicals.
My experience: I have been preparing large quantities of mixed fertilizers for some time now and haven't noticed any difference from independent dosing. Apparently, no toxic side products as well, if this is your concern (based only on healthy fish and shrimp).
Regards,
Bode
EDIT:
Actually, it has been discussed that PO4 and Fe reacts and precipitate. Indeed I have some cloudness in my mix, but it disapeers quite quickly after added to the tank. Maybe I am losing Iron and PO4???
Source:
PO4 and FE