If you can mix the powdered ingredients together without a problem, that is a good way to go. My comment was only in reference to making a liquid premix. I have tried to mix Seachem Equilibrium with water before adding it to the tank, and it just doesn't work. I end up mixing it as best I can, pouring off the milky looking water, adding more water and shaking it more, pouring off the less milky looking water, adding more water and just swirling it around so I can dump the whole thing, undissolved particles and all into the tank. And, this was with, as I recall, one half a teaspoon of Equilibrium in about 500 ml of water. My conclusion was that GH builder has to be dosed dry.